Open AccessGlutamine-supplemented total parenteral nutrition attenuates plasma interleukin-6 in surgical patients with lower disease severity
Author(s) -
Ming Lin,
Sung Pao Kung,
Sung Ling Yeh,
Koung-Yi Liaw,
Ming Yang Wang,
Ming-Jen Kuo,
Po Houng Lee,
Wei Jao Chen
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i39.6197
Subject(s) - parenteral nutrition , glutamine , medicine , gastroenterology , nitrogen balance , immunosuppression , proinflammatory cytokine , cytokine , surgery , endocrinology , amino acid , inflammation , biochemistry , chemistry , organic chemistry , nitrogen
Previous reports have shown that decrease in plasma glutamine (Gln) level following major surgery may contribute to the state of immunosuppression. Gln supplementation improves the depletion of body Gln pool, and may have indirect effect on reducing proinflammatory mediator release. This study evaluated whether the effect of Gln dipeptide-enriched total parenteral nutrition (TPN) on postoperative cytokine alteration depended on the disease severity of surgical patients.