Open AccessEndothelin-1 stimulates contraction and migration of rat pancreatic stellate cells
Author(s) -
Atsushi Masamune
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i39.6144
Subject(s) - hepatic stellate cell , protein kinase b , receptor , endothelin 1 , mapk/erk pathway , biology , cell migration , signal transduction , microbiology and biotechnology , kinase , endothelin receptor , endocrinology , chemistry , medicine , cell , biochemistry
Activated pancreatic stellate cells (PSCs) are implicated in the pathogenesis of pancreatic fibrosis and inflammation. Endothelin-1 (ET-1), which acts through G-protein coupled ET(A) and ET(B) receptors, has several biological activities. We here examined the ability of ET-1 to affect the cell functions of PSCs and the underlying molecular mechanisms.