Open AccessNF-kB and ERK-signaling pathways contribute to the gene expression induced bycagPAI-positive-Helicobacter pyloriinfection
Author(s) -
Wataru Shibata,
Yoshihiro Hirata,
Haruhiko Yoshida,
Motoyuki Otsuka,
Yujin Hoshida,
Keiji Ogura,
Shin Maeda,
Tomoya Ohmae,
Ayako Yanai,
Yuzo Mitsuno,
Naohiko Seki,
Takao Kawabe,
Masao Omata
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i39.6134
Subject(s) - biology , mapk/erk pathway , signal transduction , gene expression , helicobacter pylori , microbiology and biotechnology , gene , downregulation and upregulation , mutant , regulation of gene expression , secretion , kinase , genetics , biochemistry
To elucidate the sequential gene expression profile in AGS cells co-cultured with wild-type Helicobacter pylori (H pylori) as a model of H pylori-infected gastric epithelium, and to further examine the contribution of cag-pathogenicity islands (cagPAI)-coding type IV secretion system and the two pathways, nuclear factor kappa B (NF-kappaB) and extracellular signal-regulated kinases (ERK) on wild-type H pylori-induced gene expression.