Open AccessDifferent effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection
Author(s) -
C. Meiler,
Marcus Mühlbauer,
Monika Johann,
Arndt Hartmann,
Bernd Schnabl,
Norbert Wodarz,
Gerd Schmitz,
Jürgen Schölmerich,
Claus Hellerbrand
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i38.6031
Subject(s) - cirrhosis , alcoholic hepatitis , genotype , gastroenterology , alcoholic liver disease , medicine , liver disease , cd14 , fatty liver , immunology , genotyping , hepatitis c , chronic liver disease , disease , biology , gene , genetics , receptor
Clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a C-T (-159) polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced alcoholic liver damage. Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease (ALD) and chronic hepatitis C virus (HCV) infection.