Open AccessACEI attenuates the progression of CCl4-induced rat hepatic fibrogenesis by inhibiting TGF-β1, PDGF-BB, NF-κB and MMP-2,9
Author(s) -
Li Xu,
Ying Meng,
Xi-shan Yang,
Ling-Fei Mi,
Shaoxi Cai
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i31.4807
Subject(s) - perindopril , western blot , endocrinology , medicine , angiotensin ii , hepatic fibrosis , fibrosis , zymography , chemistry , transforming growth factor , matrix metalloproteinase , receptor , biochemistry , blood pressure , gene
Angiotensin II has pro-fibrotic function in the liver. Blockade of the renin-angiotensin-aldosterone-system (RAAS) attenuates hepatic fibrosis. The aim of the present study was to determine the mechanism of angiotensin-converting enzyme inhibitor (ACEI) on the progression of rat hepatic fibrosis.