Open AccessAssociation ofFas-670gene polymorphism with inflammatory bowel disease in Chinese patients
Author(s) -
Bing Xia,
Yuhong Yu,
Qiusha Guo,
Xiangyin Li,
Li Jiang,
Jin Li
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i3.415
Subject(s) - genotype , ulcerative colitis , inflammatory bowel disease , pathogenesis , allele , gastroenterology , gene polymorphism , immunology , lamina propria , biology , apoptosis , genotype frequency , allele frequency , medicine , disease , gene , genetics , epithelium
Recent studies suggest that Fas-mediated apoptosis is involved in the pathogenesis of inflammatory bowel disease (IBD). It has been hypothesized that either increased apoptosis of intestinal epithelium or decreased apoptosis of lamina propria lymphocytes may induce inflammation of gut. The aim of this study was to determine whether the Fas gene promoter polymorphism at position-670 was associated with IBD in Chinese patients.