Open AccessCYP2E1-dependent hepatotoxicity and oxidative damage after ethanol administration in human primary hepatocytes
Author(s) -
Liegang Liu,
Pengcheng Zhang,
Ping Yao,
Wen Zhang,
Lijun Zou,
Fang Song,
Ke Li,
Xiufa Sun
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i29.4530
Subject(s) - cyp2e1 , hepatocyte , malondialdehyde , lactate dehydrogenase , chemistry , oxidative stress , ethanol , pharmacology , western blot , biochemistry , oxidative phosphorylation , intracellular , liver injury , microbiology and biotechnology , cytochrome p450 , biology , in vitro , metabolism , enzyme , gene
To observe the relationship between ethanol-induced oxidative damage in human primary cultured hepatocytes and cytochrome P450 2E1 (CYP2E1) activity, in order to address if inhibition of CYP2E1 could attenuate ethanol-induced cellular damage.