Open AccessExpression of CD86 and increased infiltration of NK cells are associated withHelicobacter pylori-dependent state of early stage high-grade gastric MALT lymphoma
Author(s) -
SungHsin Kuo,
Li Tzong Chen,
Chi Long Chen,
Shin-Lian Doong,
Kun Tu Yeh,
Ming Shiang Wu,
Tsui Lien Mao,
Hui Chen Hsu,
Hsiu Po Wang,
Jaw Town Lin,
Ann Lii Cheng
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i28.4357
Subject(s) - helicobacter pylori , malt lymphoma , lymphoma , medicine , gastroenterology , gastric lymphoma , gastric mucosa , immunohistochemistry , pathology , stomach , immunology
A high percentage of early-stage high-grade gastric mucosa-associated lymphoid tissue (MALT) lymphomas remain Helicobacter pylori (H pylori)-dependent. However, unlike their low-grade counterparts, high-grade gastric MALT lymphomas may progress rapidly if unresponsive to H pylori eradication. It is mandatory to identify markers that may predict the H pylori-dependent status of these tumors. Proliferation of MALT lymphoma cells depends on cognate help and cell-to-cell contact of H pylori-specific intratumoral T-cells. To examine whether the expression of co-stimulatory marker CD86 (B7.2) and the infiltration of CD56 (+) natural killer (NK) cells can be useful markers to predict H pylori-dependent status of high-grade gastric MALT lymphoma.