Open AccessDifferentiation of embryonic stem cells into insulin-producing cells promoted by Nkx2.2 gene transfer
Author(s) -
Akira Shiroi,
Shigehiko Ueda,
Yukiteru Ouji,
Ko Saito,
Kyoji Moriya,
Yuko Sugie,
Hiroshi Fukui,
Shigeaki Ishizaka,
Masahide Yoshikawa
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i27.4161
Subject(s) - proinsulin , insulin , transfection , biology , cell culture , pdx1 , microbiology and biotechnology , embryoid body , cellular differentiation , medicine , pancreas , endocrinology , enteroendocrine cell , stem cell , embryonic stem cell , islet , biochemistry , adult stem cell , gene , hormone , endocrine system , genetics
To investigate the ability of a genetically altered embryonic stem (ES) cell line to generate insulin-producing cells in vitro following transfer of the Nkx2.2 gene.