Open AccessDepletion of CD25+CD4+T cells (Tregs) enhances the HBV-specific CD8+T cell response primed by DNA immunization
Author(s) -
Yoshihiro Furuichi,
Hirotake Tokuyama,
Satoshi Ueha,
Makoto Kurachi,
Fuminori Moriyasu,
Kazuhiro Kakimi
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i24.3772
Subject(s) - il 2 receptor , cytotoxic t cell , cd8 , biology , t cell , hepatitis b virus , priming (agriculture) , microbiology and biotechnology , immunology , interleukin 21 , immune system , virology , virus , in vitro , biochemistry , botany , germination
Persistent hepatitis B virus (HBV) infection is characterized by a weak CD8(+) T cell response to HBV. Immunotherapeutic strategies that overcome tolerance and boost these suboptimal responses may facilitate viral clearance in chronically infected individuals. Therefore, we examined whether CD25(+)CD4(+) regulatory T (Treg) cells might be involved in a inhibition of CD8(+) T cell priming or in the modulation of the magnitude of the 'peak' antiviral CD8(+) T cell response primed by DNA immunization.