Open AccessExpression of macrophage migration inhibitory factor is associated with enhanced angiogenesis and advanced stage in gastric carcinomas
Author(s) -
ChiaTung Shun,
JawTown Lin,
Shih-Pei Huang,
Min-Tsan Lin,
MingShiang Wu
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i24.3767
Subject(s) - macrophage migration inhibitory factor , angiogenesis , immunohistochemistry , pathology , microvessel , cd34 , medicine , neovascularization , cancer , tumor progression , inflammation , biology , cancer research , immunology , cytokine , stem cell , genetics
Macrophage migration inhibitory factor (MIF) was reported to inactivate p53 and play an essential role in the growth and angiogenesis of tumors that arise at sites of chronic inflammation. Gastric inflammation is a prerequisite for the development of gastric carcinoma (GC), which has recently been linked to Helicobacter pylori (H pylori) infection. This study aimed to investigate clinicopathological significance of MIF expression in GCs.