Open AccessHigh expressions of caveolins on the proliferating bile ductules in primary biliary cirrhosis
Author(s) -
Hiroaki Yokomori,
Masaya Oda,
Go Wakabayashi,
Masaki Kitajima,
Kazunori Yoshimura,
Masahiko Nomura,
Toshifumi Hibi
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i24.3710
Subject(s) - primary biliary cirrhosis , immunostaining , bile duct , pathology , immunohistochemistry , western blot , biology , chemistry , medicine , biochemistry , gene
An increase in bile ductular structures is observed in diverse human liver diseases, especially in primary biliary cirrhosis (PBC). These structures harbor the progenitor cell component of the liver. Caveolins are cholesterol-binding proteins involved in the regulation of several intracellular processes including cholesterol transport. This study aims to examine the role of caveolin in PBC.