Open AccessCo-expression of CDX2 and MUC2 in gastric carcinomas: Correlations with clinico-pathological parameters and prognosis
Author(s) -
Karl Rössler,
Stefan P. Mönig,
Paul M. Schneider,
FranzGeorg Hanisch,
Stephanie Landsberg,
Jüergen Thiele,
Arnulf H. Hölscher,
Hans Peter Dienes,
Stephan Baldus
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i21.3182
Subject(s) - cdx2 , intestinal metaplasia , pathology , immunohistochemistry , mucin 2 , cancer , biology , cancer research , medicine , transcription factor , gene expression , gene , homeobox , biochemistry
To evaluate the role of CDX2 homeobox protein as a predictor for cancer progression and prognosis as well as its correlation with MUC2 expression. CDX2 represents a transcription factor for various intestinal genes (including MUC2) and thus an important regulator of intestinal differentiation, which could previously be identified in gastric carcinomas and intestinal metaplasia.