Open AccessMismatch repair genes (hMLH1,hPMS1,hPMS2,GTBP/hMSH6,hMSH2) in the pathogenesis of hepatocellular carcinoma
Author(s) -
Abdel-Rahman N. Zekri,
Gelane M. Sabry,
Abeer A. Bahnassy,
Kamal A. Shalaby,
Sabrin A. Abdel-Wahabh,
S. Zakaria
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i20.3020
Subject(s) - dna mismatch repair , hepatocellular carcinoma , medicine , gene , carcinogenesis , gene expression , cirrhosis , dna repair , microbiology and biotechnology , cancer research , biology , genetics
DNA mismatch repair (MMR) is an important mechanism for maintaining fidelity of genomic DNA. Abnormalities in one or more MMR genes are implicated in the development of many cancers. We investigated the role of expression of MMR genes (hMLH1, hPMS1, hPMS2, GTBP/hMSH6, hMSH2) in hepatocellular carcinogenesis.