Open AccessResearch progress onHelicobacter pyloriouter membrane protein
Author(s) -
Shihe Shao,
Hua Wang,
Shun-Gen Chai,
Limei Liu
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i20.3011
Subject(s) - helicobacter pylori , bacterial outer membrane , pathogenicity island , pathogenicity , gastric mucosa , microbiology and biotechnology , biology , immunity , gene , immunology , immune system , virulence , stomach , genetics , escherichia coli , biochemistry
Helicobacter pylori (H pylori), one of the most common bacterial pathogens on human beings, colonizes the gastric mucosa. In its 95 paralogous gene families, there is a large outer membrane protein (OMP) family. It includes 32 members. These OMP are important for the diagnosis, protective immunity, pathogenicity of H pylori and so on. They are significantly associated with high H pylori density, the damage of gastric mucosa, high mucosal IL-8 levels and severe neutrophil infiltration. We introduce their research progress on pathogenicity.