Open AccessHomozygosity for Pro of p53 Arg72Pro as a potential risk factor for hepatocellular carcinoma in Chinese population
Author(s) -
Zhongzheng Zhu,
WenMing Cong,
Shufang Liu,
Hui Dong,
Guoqiang Zhu,
Meng-Chao Wu
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i2.289
Subject(s) - odds ratio , genotype , hepatocellular carcinoma , medicine , allele , confidence interval , gastroenterology , logistic regression , heterozygote advantage , population , oncology , case control study , biology , genetics , gene , environmental health
Codon 72 exon 4 polymorphism (Arg72Pro) of the p53 gene has been implicated in cancer risk. Our objective was to investigate the possible association between p53 Arg72Pro polymorphism and susceptibility to hepatocellular carcinoma (HCC) among Chinese population.