Open AccessClinical usefulness of biochemical markers of liver fibrosis in patients with nonalcoholic fatty liver disease
Author(s) -
Hiroshi Sakugawa,
Tomofumi Nakayoshi,
Kasen Kobashigawa,
Tsuyoshi Yamashiro,
Tatsuji Maeshiro,
Satoru Miyagi,
Joji Shiroma,
Akiyo Toyama,
Tomokuni Nakayoshi,
Fukunori Kinjo,
Atsushi Saito
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i2.255
Subject(s) - nonalcoholic fatty liver disease , fibrosis , hyaluronic acid , medicine , gastroenterology , fatty liver , hepatic fibrosis , chronic liver disease , pathology , liver disease , steatohepatitis , type iv collagen , disease , cirrhosis , biology , extracellular matrix , biochemistry , laminin , anatomy
Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD), and progresses to the end stage of liver disease. Biochemical markers of liver fibrosis are strongly associated with the degree of histological liver fibrosis in patients with chronic liver disease. However, data are few on the usefulness of markers in NAFLD patients. The aim of this study was to identify better noninvasive predictors of hepatic fibrosis, with special focus on markers of liver fibrosis, type VI collagen 7S domain and hyaluronic acid.