Open AccessGeneration of the regulatory protein rtTA transgenic mice
Author(s) -
Kang Xu,
Xin-Yan Deng,
Ying Ye,
Guo Z,
Bing Huang,
Xiaozhen Hong,
Dong Xiao,
Chen Xi-gu
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i19.2885
Subject(s) - transgene , biology , genetically modified mouse , microbiology and biotechnology , gene , virology , genetics
To translate Tet-on system into a conditional mouse model, in which hepatitis B or C virus (HBV or HCV) gene could be spatiotemporally expressed to overcome "immune tolerance" formed during the embryonic development and "immune escape" against hepatitis virus antigen(s), an effector mouse, carrying the reverse tetracycline-responsive transcriptional activator (rtTA) gene under the tight control of liver-specific human apoE promoter, is required to be generated.