Open AccessInvolvement of fatty acid-CoA ligase 4 in hepatocellular carcinoma growth: Roles of cyclic AMP and p38 mitogen-activated protein kinase
Author(s) -
Yu Chih Liang,
Chih Hsiung Wu,
Jan Show Chu,
Chung Kwe Wang,
Ling Fang Hung,
Ying Jan Wang,
Yuan Soon Ho,
JuiHsing Chang,
Shyr Yi Lin
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i17.2557
Subject(s) - gene knockdown , carcinogenesis , small interfering rna , cancer research , biology , cell growth , mapk/erk pathway , signal transduction , protein kinase a , cell culture , kinase , microbiology and biotechnology , dna ligase , transfection , gene , biochemistry , genetics
Fatty acid-CoA ligase 4 (FACL4) is an arachidonate-preferring enzyme which has been shown to be up-regulated in human colon cancer tissues and implicated in the colon tumorigenesis. The purpose of this study was to investigate the role of FACL4 in the human hepatocellular carcinoma (HCC) tumorigenesis and the specific signal pathways involved in this process.