Open AccessEffect of ZVAD-fmk on hepatocyte apoptosis after bile duct ligation in rat
Author(s) -
Shyr Ming Sheen-Chen,
Hsin Tsung Ho,
Wei-Jen Chen,
Hock Liew Eng
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i15.2330
Subject(s) - hepatocyte , apoptosis , ligation , medicine , programmed cell death , biology , chemistry , endocrinology , biochemistry , in vitro
Retention and accumulation of toxic hydrophobic bile salts within hepatocyte may cause hepatocyte toxicity by inducing apoptosis. Apoptosis is a pathway of cell death orchestrated by a family of proteases called caspases. Z-Val-Ala-Asp (OMe)-fluoromethyl ketone (ZVAD-fmk) is a cell-permeable irreversible inhibitor of caspase. The purpose of this study was to evaluate the possible effect of ZVAD-fmk on hepatocyte apoptosis after bile duct ligation in the rat.