Open AccessInhibitory effect of human telomerase antisense oligodeoxyribonucleotides on the growth of gastric cancer cell lines in variant tumor pathological subtype
Author(s) -
Jing Ye,
Yun Wu,
Shu Zhang,
Zi Chen,
Lixia Guo,
Ruoyu Zhou,
Hong Xie
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i15.2230
Subject(s) - telomerase , microbiology and biotechnology , biology , cell culture , telomerase reverse transcriptase , cancer cell , cell growth , cancer , antisense rna , apoptosis , growth inhibition , cancer research , rna , biochemistry , genetics , gene
To investigate the inhibitory effect of specialized human telomerase antisense oligodeoxyribonucleotides on the growth of well (MKN-28), moderately (SGC-7901) and poorly (MKN-45) differentiated gastric cancer cell lines under specific conditions and its inhibition mechanism, and to observe the correlation between the growth inhibition ratio and the tumor pathologic subtype of gastric cancer cells.