Open AccessRole of insulin/insulin-like growth factor 1 signaling pathway in longevity
Author(s) -
Chun-Lei Cheng,
Tian-Qin Gao,
Zhen Wang,
Dian-Dong Li
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i13.1891
Subject(s) - longevity , biology , drosophila melanogaster , insulin receptor , signal transduction , saccharomyces cerevisiae , insulin , tor signaling , insulin like growth factor , caenorhabditis elegans , growth factor , cell signaling , insulin resistance , microbiology and biotechnology , genetics , endocrinology , yeast , gene , receptor
The insulin/insulin-like growth factor 1 (IGF-1) signaling pathway is evolutionary conserved in diverse species including C.elegans, saccharomyces cerevisiae, Drosophila melanogaster, rodents and humans, which is involved in many interrelated functions that are necessary for metabolism, growth and reproduction. Interestingly, more and more research has revealed that insulin/IGF-1 signaling pathway plays a pivotal role in the regulation of longevity. Generally, disruption of the power of this pathway will extend longevity in species ranging from C.elegans to humans. The role of insulin/IGF-1 in longevity is probably related to stress resistance. Although the underlying mechanisms of longevity are not fully understood, the Insulin/IGF-1 signaling pathway has attracted substantial attention and it will be a novel target to prevent or postpone age-related diseases and extend life span. In this review, we mainly focus on the similar constitution and role of insulin/IGF-1 signaling pathway in C.elegans, saccharomyces cerevisiae, rodents and humans.