Open AccessDetailed deletion mapping of loss of heterozygosity on 22q13 in sporadic colorectal cancer
Author(s) -
Haitao Zheng,
Zhihai Peng,
Chongzhi Zhou,
Dapeng Li,
Zhaowen Wang,
Guoqiang Qiu,
Lin He
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i11.1668
Subject(s) - loss of heterozygosity , locus (genetics) , colorectal cancer , carcinogenesis , biology , metastasis , microsatellite , tumor suppressor gene , cancer research , tumor progression , chromosome , gene , cancer , genetics , allele
Both development and progression of malignancies occur as a multistep process, requiring the activation of oncogenes and the inactivation of several tumor suppressor genes. The loss of heterozygosity (LOH) of tumor suppressor genes is believed to play a key role in carcinogenesis of colorectal cancer (CRC). In this study, we analyzed the LOH of seven loci on chromosome 22q13 in an effort to identify candidate tumor suppressor genes involved in colorectal carcinogenesis.