Open AccessSirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth
Author(s) -
Guido Schumacher,
M. Oidtmann,
Anne Rueggeberg,
Dietmar Jacob,
Sven Jonas,
Jan M. Langrehr,
R. Neuhaus,
Marcus Bahra,
Peter Neuhaus
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i10.1420
Subject(s) - tacrolimus , sirolimus , apoptosis , cell growth , hepatocellular carcinoma , growth inhibition , cell culture , hep g2 , cancer research , transplantation , biology , chemistry , pharmacology , medicine , biochemistry , genetics
Standard immunosuppression after organ transplantation stimulates tumor growth. Sirolimus has a strong antiproliferative and a tumor inhibiting effect. The purpose is to assess the effect on tumor growth of the immuno-suppressive compounds sirolimus and tacrolimus alone and in combination on cells of human hepatocellular carcinoma.