Open AccessExpression patterns of transforming growth factor-beta and its receptors in gastric mucosa of patients with refractory gastric ulcer
Author(s) -
ShouChuan Shih
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i1.136
Subject(s) - immunohistochemistry , in situ hybridization , biopsy , medicine , receptor , gastric mucosa , gastroenterology , pathology , transforming growth factor beta , stomach , gene expression , biology , gene , biochemistry
Transforming growth factor-beta (TGF-beta) plays a regulatory role in tissue repair. In a previous study, we found that TGF-beta and its receptors were expressed in gastric mucosa of patients with well-healed gastric ulcers, as demonstrated by immunohistochemistry. To further characterize the role of TGF-beta and its receptors in repairing gastric ulcers, we investigated the expression patterns of TGF-beta and its receptors in gastric mucosa by in situ hybridization and reverse transcriptase-polymerase chain reaction (RT-PCR).