Expression patterns of transforming growth factor-beta and its receptors in gastric mucosa of patients with refractory gastric ulcer | Zendy

ShouChuan Shih | Zendy

Open Access

Expression patterns of transforming growth factor-beta and its receptors in gastric mucosa of patients with refractory gastric ulcer

Author(s) -

ShouChuan Shih

Publication year - 2005

Publication title -

world journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 155

eISSN - 2219-2840

pISSN - 1007-9327

DOI - 10.3748/wjg.v11.i1.136

Subject(s) - immunohistochemistry , in situ hybridization , biopsy , medicine , receptor , gastric mucosa , gastroenterology , pathology , transforming growth factor beta , stomach , gene expression , biology , gene , biochemistry

Transforming growth factor-beta (TGF-beta) plays a regulatory role in tissue repair. In a previous study, we found that TGF-beta and its receptors were expressed in gastric mucosa of patients with well-healed gastric ulcers, as demonstrated by immunohistochemistry. To further characterize the role of TGF-beta and its receptors in repairing gastric ulcers, we investigated the expression patterns of TGF-beta and its receptors in gastric mucosa by in situ hybridization and reverse transcriptase-polymerase chain reaction (RT-PCR).

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