Open AccessEradication ofHelicobacter pylorisignificantly reduced gastric damage in nonsteroidal anti-inflammatory drug-treated Mongolian gerbils
Author(s) -
Chun Chao Chang,
Sheng-Hsuan Chen,
Gi Shih Lien,
Horng Yuan Lou,
Ching Ruey Hsieh,
Chia Lang Fang,
Sheng-Wei Pan
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i1.104
Subject(s) - rofecoxib , medicine , gastroenterology , helicobacter pylori , stomach , gastritis , myeloperoxidase , prostaglandin , gerbil , cyclooxygenase , inflammation , chemistry , enzyme , biochemistry , ischemia
To examine the effect of eradication of Helicobacter pylori prior to usage of NSAIDs, by investigating gastric inflammatory activity, myeloperoxidase (MPO) activity, prostaglandin (PG) E2 synthesis in H pylori-infected, and H pylori-eradicated gerbils followed by administration of indomethacin and rofecoxib.