Open AccessEstablishment of a P-glycoprotein substrate screening model and its preliminary application
Author(s) -
Yi Wang,
Jiang Cao,
Shaohua Zeng
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i9.1365
Subject(s) - microbiology and biotechnology , transfection , complementary dna , recombinant dna , plasmid , western blot , biology , cell culture , lipofectamine , expression vector , p glycoprotein , vector (molecular biology) , dna , gene , drug resistance , biochemistry , multiple drug resistance , genetics
To establish a high P-glycoprotein (P-gp) expressing cell line as a model for studying drug absorption and distribution, and to explore the preliminary application of this screening model.