Open AccessVascular endothelial growth factor antisense oligodeoxynucleotides with lipiodol in arterial embolization of liver cancer in rats
Author(s) -
Han-Ping Wu,
Feng Gao,
Huimin Liang,
Chuansheng Zheng,
Xin Li
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i6.813
Subject(s) - lipiodol , angiogenesis , vascular endothelial growth factor , medicine , hepatocellular carcinoma , basic fibroblast growth factor , metastasis , arterial embolization , liver cancer , pathology , immunohistochemistry , growth factor , embolization , cancer research , cancer , vegf receptors , surgery , receptor
Transcatheter arterial embolization (TAE) of the hepatic artery has been accepted as an effective treatment for unresectable hepatocellular carcinoma (HCC). However, embolized vessel recanalization and collateral circulation formation are the main factors of HCC growth and recurrence and metastasis after TAE. Vascular endothelial growth factor (VEGF) plays an important role in tumor angiogenesis. This study was to explore the inhibitory effect of VEGF antisense oligodeoxynucleotides (ODNs) on VEGF expression in cultured Walker-256 cells and to observe the anti-tumor effect of intra-arterial infusion of antisense ODNs mixed with lipiodol on rat liver cancer.