Open AccessModulation of human telomerase reverse transcriptase in hepatocellular carcinoma
Author(s) -
ChengJueng Chen,
Satoru Kyo,
Yao–Chi Liu,
Yeung-Leung Cheng,
Chung-Bao Hsieh,
DeChuan Chan,
Jyh-Cherng Yu,
HorngJyh Harn
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i5.638
Subject(s) - telomerase reverse transcriptase , telomerase , microbiology and biotechnology , luciferase , promoter , transfection , biology , cell culture , messenger rna , cancer research , gene expression , transcription (linguistics) , hepatocellular carcinoma , gene , chemistry , genetics , linguistics , philosophy
Most cancer cells acquire immortal capability by telomerase activation. The human telomerase reverse transcriptase gene (hTERT) is considered to be the major determinant of the enzymatic activity of human telomerase, and the hTERT promoter contains several c-Myc binding sites that mediate hTERT transcriptional activation. Few studies have examined the role of hTERT in hepatocarcinogenesis, and the relationship between c-Myc and telomerase in human hepatocellular carcinoma tissue is unknown.