Open AccessHelicobacterspecies sequences in liver samples from patients with and without hepatocellular carcinoma
Author(s) -
Rinaldo Pellicano,
Vincenzo Mazzaferro,
Francesco Grigioni,
Miguel Angel Cutufia,
Sharmila Fagoonee,
Lorenzo Silengo,
Mario Rizzetto,
Antonio Ponzetto
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i4.598
Subject(s) - hepatocellular carcinoma , cirrhosis , helicobacter pylori , helicobacter , gastroenterology , hepatitis c virus , medicine , liver cancer , colorectal cancer , metastasis , cancer , pathology , virus , virology
Only a minority of patients carrying a defined viral aetiologic agent develop cirrhosis and ultimately hepatocellular carcinoma (HCC), the mechanism underlying the worsening is still undefined. Experimental infection by Helicobacter hepaticus in mice causes chronic hepatitis and HCC and recently, more Helicobacter species (Helicobacter spp.) have been detected in the liver of patients suffering from cholestatic diseases and HCC arising from non-cirrhotic liver. We investigated whether Helicobacter spp. sequences could be detected in the liver of patients with cirrhosis and HCC compared to subjects with metastasis to liver from colon cancer.