Open AccessViral replication modulated by synthetic peptide derived from hepatitis B virus X protein
Author(s) -
Song Chang-zheng,
Qingwei Wang,
Changcheng Song,
Zhenzhong Bai
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i3.389
Subject(s) - hbeag , hbsag , biology , intracellular , microbiology and biotechnology , hepatitis b virus , flow cytometry , viral replication , extracellular , peptide , virology , virus , biochemistry
A strategy for viral vaccine design is the use of conserved peptides to overcome the problem of sequence diversity. At present it is still unclear whether conserved peptide is safe as a candidate vaccine. We reported it here for the first time not only to highlight the biohazard issue and safety importance for viral peptide vaccine, but also to explore the effect of a fully conserved peptide on HBV replication within the carboxyl terminus of HBx.