Open AccessA novel genetic polymorphism of inducible nitric oxide synthase is associated with an increased risk of gastric cancer
Author(s) -
Jing Shen
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i22.3278
Subject(s) - odds ratio , genotype , helicobacter pylori , gastroenterology , medicine , caga , cancer , nitric oxide synthase , genotyping , biology , nitric oxide , genetics , gene , virulence
Inducible nitric oxide synthase (iNOS) plays a central role in the pathway of reactive oxygen and nitrogen species metabolism when Helicobacter pylori (H pylori) infection occurs in humans. iNOS Ser(608)Leu allele, a novel genetic polymorphism (C/T) occurring within exon 16 of the iNOS reductase domain, may have a dramatic effect on the enzymatic activity. The aim of this study was to determine whether iNOS C/T polymorphism was associated with increased susceptibility to gastric cancer.