Open AccessEnhancement of osteopontin expression in HepG2 cells by epidermal growth factor via phosphatidylinositol 3-kinase signaling pathway
Author(s) -
Guoxin Zhang,
Zhi-quan Zhao,
Hong-Di Wang,
Bo Hao
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i2.205
Subject(s) - osteopontin , wortmannin , epidermal growth factor , signal transduction , pi3k/akt/mtor pathway , cancer research , biology , microbiology and biotechnology , endocrinology , biochemistry , receptor
Osteopontin (OPN) is a phosphorylated glycoprotein with diverse functions including cancer development, progression and metastasis. It is unclear how osteopontin is regulated in HepG2 cells. The aim of this study was to investigate the effect of epidermal growth factor on the expression of osteopontin in HepG2 cells, and to explore the signal transduction pathway mediated this expression.