Open AccessCorrelation of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase with sensitivity of gastrointestinal cancer cells to 5-fluorouracil and 5-fluoro-2’-deoxyuridine
Author(s) -
Tao Ma,
Zhenggang Zhu,
Yu-Bao Ji,
Yi Zhang,
Yingyan Yu,
Bingya Liu,
Hao Yin,
Yuxin Lin
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i2.172
Subject(s) - thymidylate synthase , dihydropyrimidine dehydrogenase , thymidine phosphorylase , deoxyuridine , fluorouracil , ic50 , gastrointestinal cancer , thymidine , chemistry , microbiology and biotechnology , enzyme , biology , cancer , biochemistry , medicine , colorectal cancer , in vitro , dna
To determine the expression levels of three metabolic enzymes of fluoropyrimidines: thymidylate synthase (TS), thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) in seven human gastrointestinal cancer cell lines, and to compare the enzyme levels with the sensitivity to 5-fluorouracil (5-FU) and 5-fluoro-2'-deoxyuridine (FdUrd).