Correlation of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase with sensitivity of gastrointestinal cancer cells to 5-fluorouracil and 5-fluoro-2’-deoxyuridine | Zendy

Tao Ma | Zendy; Zhenggang Zhu | Zendy; Yu-Bao Ji | Zendy; Yi Zhang | Zendy; Yingyan Yu | Zendy; Bingya Liu | Zendy; Haoran Yin | Zendy; Yan-Zhen Lin | Zendy

Open Access

Correlation of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase with sensitivity of gastrointestinal cancer cells to 5-fluorouracil and 5-fluoro-2’-deoxyuridine

Author(s) -

Tao Ma,

Zhenggang Zhu,

Yu-Bao Ji,

Yi Zhang,

Yingyan Yu,

Bingya Liu,

Haoran Yin,

Yan-Zhen Lin

Publication year - 2004

Publication title -

world journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 155

eISSN - 2219-2840

pISSN - 1007-9327

DOI - 10.3748/wjg.v10.i2.172

Subject(s) - thymidylate synthase , dihydropyrimidine dehydrogenase , thymidine phosphorylase , deoxyuridine , fluorouracil , ic50 , gastrointestinal cancer , thymidine , chemistry , microbiology and biotechnology , enzyme , biology , cancer , biochemistry , medicine , colorectal cancer , in vitro , dna

To determine the expression levels of three metabolic enzymes of fluoropyrimidines: thymidylate synthase (TS), thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) in seven human gastrointestinal cancer cell lines, and to compare the enzyme levels with the sensitivity to 5-fluorouracil (5-FU) and 5-fluoro-2'-deoxyuridine (FdUrd).

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