Open AccessTegaserod inhibits noxious rectal distention induced responses and limbic system c-Fos expression in rats with visceral hypersensitivity
Author(s) -
Hongmei Jiao,
Ping Xie
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i19.2836
Subject(s) - tegaserod , saline , medicine , anesthesia , visceral pain , agonist , serotonin , tropisetron , nociception , receptor , irritable bowel syndrome
To examine the effects of tegaserod, a serotonin (5-HT) 4 receptor partial agonist, on abdominal withdrawal reflex (AWR) to rectal distention (RD) and c-Fos expression in limbic system.