Open AccessRoles ofHelicobacter pyloriinfection and cyclooxygenase-2 expression in gastric carcinogenesis
Author(s) -
Wei Sun,
Yu Qian,
Hong Shen,
Xilong Ou,
Dazhong Cao,
Yasuyuki Takata,
Qian Cheng,
Feng Zhu,
Yihong Sun,
Xi-Ling Fu,
Han Su
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i19.2809
Subject(s) - intestinal metaplasia , helicobacter pylori , dysplasia , cancer , medicine , gastroenterology , rapid urease test , carcinogenesis , gastric mucosa , gastritis , atrophic gastritis , immunohistochemistry , stomach , pathology , chronic gastritis
Cyclooxygenase (COX)-2 is over expressed in gastrointestinal neoplasm. Helicobacter pylori (H pylori) infection is causally linked to gastric cancer. However, the expression of COX-2 in various stages of H pylori-associated gastric carcinogenesis pathway has not been elucidated. Therefore, the aim of this study was to clarify the role of H pylori induced COX-2 expression during carcinogenesis in the stomach.