Open AccessEffects of endothelin-1 on hepatic stellate cell proliferation, collagen synthesis and secretion, intracellular free calcium concentration
Author(s) -
Chuanyong Guo,
Jianye Wu,
YunBin Wu,
Ming Zhong,
Huichao Lu
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i18.2697
Subject(s) - hepatic stellate cell , verapamil , calcium , dna synthesis , medicine , endothelin 1 , endocrinology , secretion , egta , microbiology and biotechnology , chemistry , in vitro , biology , biochemistry , receptor
To explore the effects of endothelin-1(ET-1) on hepatic stellate cells (HSCs) DNA uptake, DNA synthesis, collagen synthesis and secretion, inward whole-cell calcium concentration ([Ca2+]i) as well as the blocking effect of verapamil on ET-1-stimulated release of inward calcium (Ca2+) of HSC in vitro.