Open Access4-hydroxy-2, 3-nonenal activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells
Author(s) -
Kazuhiro Kikuta,
Atsushi Masamune,
Masahiro Satoh,
Noriaki Suzuki,
Tooru Shimosegawa
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i16.2344
Subject(s) - hepatic stellate cell , kinase , p38 mitogen activated protein kinases , mapk/erk pathway , mitogen activated protein kinase , signal transduction , protein kinase a , microbiology and biotechnology , activator (genetics) , ask1 , biology , chemistry , biochemistry , mitogen activated protein kinase kinase , endocrinology , receptor
Activated pancreatic stellate cells (PSCs) are implicated in the pathogenesis of pancreatic inflammation and fibrosis, where oxidative stress is thought to play a key role. 4-hydroxy-2,3-nonenal (HNE) is generated endogenously during the process of lipid peroxidation, and has been accepted as a mediator of oxidative stress. The aim of this study was to clarify the effects of HNE on the activation of signal transduction pathways and cellular functions in PSCs.