Open AccessAlverine citrate induced acute hepatitis
Author(s) -
Mehmet Arhan,
Seyfettin Köklü,
Aydln S Köksal,
Ömer Faruk Yolcu,
Senem Koruk,
İrfan Koruk,
Ertuğrul Kayaçeti̇n
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i15.2303
Subject(s) - toxicity , medicine , hepatitis , etiology , acute hepatitis , toxic hepatitis , pharmacology
Alverine citrate is a commonly used smooth muscle relaxant agent. A MEDLINE search on January 2004 revealed only 1 report implicating the hepatotoxicity of this agent. A 34-year-old woman was investigated because of the finding of elevated liver function tests on biochemical screening. Other etiologies of hepatitis were appropriately ruled out and elevated enzymes were ascribed to alverine citrate treatment. Although alverine citrate hepatotoxicity was related to an immune mechanism in the first case, several features such as absence of predictable dose-dependent toxicity of alverine citrate in a previous study and absence of hypersensitivity manifestations in our patient are suggestive of a metabolic type of idiosyncratic toxicity.