Open AccessInfluence of serum from liver-damaged rats on differentiation tendency of bone marrow-derived stem cells
Author(s) -
Hai Hong,
Jianzhi Chen,
Feng Zhou,
Ling Xue,
Guoqiang Zhao
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i15.2250
Subject(s) - stem cell , bone marrow stem cell , bone marrow , biology , cellular differentiation , hepatocyte , microbiology and biotechnology , isozyme , stem cell marker , immunology , biochemistry , enzyme , in vitro , gene
Recent studies in both rodents and humans indicated that bone marrow (BM)-derived stem cells were able to home to the liver after they were damaged and demonstrated plasticity in becoming hepatocytes. However, the question remains as to how these stem cells are activated and led to the liver and where the signals initiating the mechanisms of activation and differentiation of stem cells originate. The aim of this study was to investigate the influence of serum from liver-damaged rats on differentiation tendency of bone marrow-derived stem cells.