Open AccessHCV NS5A abrogates p53 protein function by interfering with p53-DNA binding
Author(s) -
Guozhong Gong,
Yongfang Jiang,
Yan He,
Li-Ying Lai,
Yingting Zhu,
Xian-shi Su
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i15.2223
Subject(s) - transactivation , luciferase , microbiology and biotechnology , transfection , ns5a , electrophoretic mobility shift assay , expression vector , biology , promoter , reporter gene , western blot , gene expression , gene , chemistry , biochemistry , recombinant dna , hepacivirus , genotype
To evaluate the inhibition effect of HCV NS5A on p53 transactivation on p21 promoter and explore its possible mechanism for influencing p53 function.