Open AccessManagement of carbon tetrachloride-induced acute liver injury in rats by syngeneic hepatocyte transplantation in spleen and peritoneal cavity
Author(s) -
Charalampos Pilichos,
Despina Perrea,
Maria Demonakou,
Athena Preza,
Ismini Donta
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i14.2099
Subject(s) - carbon tetrachloride , medicine , transplantation , peritoneal cavity , saline , spleen , gastroenterology , abdominal cavity , hepatocyte , histology , pathology , liver transplantation , alkaline phosphatase , intraperitoneal injection , parenchyma , surgery , chemistry , in vitro , biochemistry , organic chemistry , enzyme
Acute hepatitis may seldom have a fulminant course. In the treatment of this medical emergency, potential liver support measure must provide immediate and sufficient assistance to the hepatic function. The goal of our study was to study the adequacy of hepatocyte transplantation (HCTx) in two different anatomical sites, splenic parenchyma and peritoneal cavity, in a rat model of reversible acute hepatitis induced by carbon tetrachloride (CCl(4)).