Open AccessExpression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic adenocarcinoma: Correlation with microvessel density
Author(s) -
Haino Uwe Kasper,
Hella Wolf,
Uta Drebber,
Helmut K. Wolf,
Michael Kern
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i13.1918
Subject(s) - nitric oxide synthase , carcinogenesis , immunohistochemistry , adenocarcinoma , angiogenesis , microvessel , cyclooxygenase , pathology , cancer research , nitric oxide , biology , chemistry , medicine , enzyme , cancer , biochemistry
Cyclooxygenases (COX) are key enzymes for conversion of arachidonic acid to prostaglandins. Nitric oxide synthase (NOS) is the enzyme responsible for formation of nitric oxide. Both have constitutive and inducible isoforms. The inducible isoforms (iNOS and COX-2) are of great interest as regulators of tumor angiogenesis, tumorigenesis and inflammatory processes. This study was to clarify their role in pancreatic adenocarcinomas.