Open AccessTherapeutic polypeptides based on HBV core 18-27 epitope can induce CD8+CTL-mediated cytotoxicity in HLA-A2+human PBMCs
Author(s) -
Tao Shi,
Yuzhang Wu,
Zhengcai Jia,
Liyun Zou,
Weiping Zhou
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i13.1902
Subject(s) - epitope , ctl* , immunogenicity , cytotoxic t cell , cd8 , peripheral blood mononuclear cell , virology , t cell , antigen , hbcag , cytotoxicity , human leukocyte antigen , biology , hepatitis b virus , immunology , microbiology and biotechnology , immune system , in vitro , hbsag , virus , biochemistry
To explore how to improve the immunogenicity of HBcAg CTL epitope based polypeptides and to trigger an HBV-specific HLA I-restricted CD8+ T cell response in vitro.