Open AccessHeme oxygenase-1 in cholecystokinin-octapeptipe attenuated injury of pulmonary artery smooth muscle cells induced by lipopolysaccharide and its signal transduction mechanism
Author(s) -
Xinli Huang,
Yi-Ling Ling,
Yibei Ling,
Jun-Lin Zhou,
Yan Liu,
Qiuhong Wang
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i12.1789
Subject(s) - heme oxygenase , western blot , signal transduction , lipopolysaccharide , microbiology and biotechnology , immunocytochemistry , medicine , endocrinology , malondialdehyde , chemistry , biology , heme , biochemistry , oxidative stress , enzyme , gene
To study the effect of cholecystokinin-octapeptide (CCK-8) on lipopolysaccharide (LPS) -induced pulmonary artery smooth muscle cell (PASMCs) injury and the role of heme oxygenase-1 (HO-1), and to explore the regulation mechanism of c-Jun N-terminal kinase (JNK) and activator protein-1 (AP-1) signal transduction pathway in inducing HO-1 expression further.