Open AccessInhibition of Fas/FasL mRNA expression and TNF-α release in concanavalin A-induced liver injury in mice by bicyclol
Author(s) -
Min Li,
Geng-Tao Liu
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i12.1775
Subject(s) - fas ligand , liver injury , tumor necrosis factor alpha , concanavalin a , apoptosis , alanine transaminase , endocrinology , interferon gamma , cytokine , messenger rna , medicine , microbiology and biotechnology , chemistry , biology , biochemistry , programmed cell death , in vitro , gene
Bicyclol, 4, 4'-dimethoxy-5, 6, 5', 6'-dimethylene-dioxy-2-hydroxymethyl -2'-carbonyl biphenyl, is a new anti-hepatitis drug. The aim of the present study was to investigate the protective effect of bicyclol on concanavalin A (Con A)-induced immunological liver injury in mice and its mechanism.