Open AccessTumor type M2pyruvate kinase expression in gastric cancer, colorectal cancer and controls
Author(s) -
Bo Zhang,
Jianying Chen,
Chen Daoda,
Guobin Wang,
Ping Shen
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i11.1643
Subject(s) - pyruvate kinase , cancer , colorectal cancer , metastasis , tumor m2 pk , medicine , glycolysis , gastroenterology , stage (stratigraphy) , tumor marker , tumor progression , pathology , oncology , biology , metabolism , paleontology
Tumor formation is generally linked to an expansion of glycolytic phosphometabolite pools and aerobic glycolytic flux rates. To achieve this, tumor cells generally overexpress a special glycolytic isoenzyme, termed pyruvate kinase type M(2). The present study was designed to evaluate the use of a new tumor marker, tumor M(2)-PK, in discriminating gastrointestinal cancer patients from healthy controls, and to compare with the reference tumor markers CEA and CA72-4.