Open AccessLeflunomide attenuates hepatocyte injury by inhibiting Kupffer cells
Author(s) -
Hongwei Yao,
Jun Li,
Jiqiang Chen,
Shaochun Xu
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i11.1608
Subject(s) - leflunomide , hepatocyte , liver injury , pharmacology , medicine , chemistry , in vitro , biochemistry , rheumatoid arthritis
To investigate the importance of direct contact between Kupffer cells (KCs) and hepatocytes (HCs) during hepatic inflammatory responses, and the effect of leflunomide's active metabolite, A(771726), on cytokines in KCs, HCs and KC cocultures (DC cocultures).