Open AccessPotential role ofp53 mutation in chemical hepatocarcinogenesis of rats
Author(s) -
Wei-Guo Deng,
Yan Fu,
Yulin Li,
Toshihiro Sugiyama
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i1.46
Subject(s) - carcinogenesis , microdissection , exon , point mutation , biology , missense mutation , microbiology and biotechnology , immunostaining , mutation , laser capture microdissection , gene , mutant , gene mutation , messenger rna , gene expression , cancer research , pathology , genetics , immunohistochemistry , medicine , immunology
Inactivation of p53 gene is one of the most frequent genetic alterations in carcinogenesis. The mutation status of p53 gene was analyzed, in order to understand the effect of p53 mutation on chemical hepatocarcinogenesis of rats.