Open AccessDifferences in proximal (cardia) versus distal (antral) gastric carcinogenesis via retinoblastoma pathway
Author(s) -
Christian Gulmann,
Helen Hegarty,
Antoinette Grace,
M. Leader,
Stephen Patchett,
Elaine W. Kay
Publication year - 2004
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v10.i1.17
Subject(s) - intestinal metaplasia , antrum , carcinogenesis , immunohistochemistry , metaplasia , cancer , retinoblastoma , pathology , concomitant , stomach , medicine , carcinoma , biology , gastroenterology , gene , biochemistry
Disruption of cell cycle regulation is a critical event in carcinogenesis, and alteration of the retinoblastoma (pRb) tumour suppressor pathway is frequent. The aim of this study was to compare alterations in this pathway in proximal and distal gastric carcinogenesis in an effort to explain the observed striking epidemiological differences.